Description

During the past decades cardiovascular magnetic resonance (CMR) has evolved into a new advanced technique for diagnosis of wide spectrum of acquired and congenital heart diseases. The method offers not only accurate and high-resolution analysis of structural anomalies, but also allows exact quantification of functional aspects including valvular pathologies and “in vivo pathology” through its ability to accurately depict myocardial anomalies.

The department of Cardiology has put great efforts and human resources into expanding its capacities for clinical CMR in order to meet current and future demands. It is currently offering state-of-the art examinations with the newest available technologies including CINE imaging, 3D angiography, myocardial tissue characterization, stress imaging (adenosine perfusion or dobutamine stress), phase contrast flow measurements and 3D whole heart imaging for evaluation of proximal coronary anatomy or un-corrected congenital heart disease. We have great interest in developing new CMR technologies and setting new standards for targeted interventions in cooperation with other research groups and industry partners.

For best efficiency, a CMR research group including a physicists is being created which will closely collaborate with partners of the industry.

 Focus

  • Individualised learning and patient-tailored planning tool for cardiac surgeons and interventional cardiologists for patients with congenital heart disease with 3D segmentation of cardiac-thoracic structures and myocardial scars (project already in progress in close collaboration with the Artorg Center, the Department for Adult and Pediatric Cardiology and Cardiac Congenital Surgery).
  • Determination of predictors of outcomes in patients undergoing interventional valve implantation or repair (e.g. TAVI, Mitraclip) by characterisation of myocardial structure and injury as well as functional reserve.
    - Development of MR-conditional devices.
    - Bioptome for myocardial biopsies.
  • Epicardial pacemaker electrodes (currently not available but increasing need for children/adults with congenital heart disease or patients after endovascular electrode infections).
  • MR guided endomyocardial biopsy.
  • Characterisation of atrial structure in patients with atrial fibrillation by high resolution imaging of atrial anatomy and scarring (7 Tesla).
    - in order to find predictors for successful ablation.
    - for guided (re-) intervention targeted to atrial pathology.
  • Real-time MR-guiding with MR-conditional catheters for a combined MR biventricular volume/function and flow-derived + MR-conditional catheter-pressure derived evaluation for cardiac shunts and pulmonary hypertension (with pressure, flow, resistance and wave intensities) in patients with hereditary or acquired pulmonary hypertension without the use of radiation.
  • Development and use of MR-conditional catheters and valve or thoracic vessel prostheses for an advanced complete anatomic and functional pathyphysiologic exam for valve dysfunction and evaluation of the functional integrity of the implanted devices (implantation of valve or thoracic vessels prosthesis before and after) maybe added with an electrophysiologic study and ablation for arrhythmia.
  • To determine impact of physical exercise on right ventricular function and structure in patients with congenital heart disease (grant Swiss Heart Foundation).