Description

Stroke is a devastating disease with a high morbidity and mortality. Therefore, improvement of diagnosis and management of acute stroke patients is the most important challenge in order to improve outcome of these heavily affected patients. Multimodal brain and vessel imaging is the backbone of acute stroke therapy and helps to select patients for various therapeutic approaches. Furthermore, imaging is crucial to establish prognosis after an acute stroke. Several ongoing and planned research projects aim to improve patient selection, acute stroke management and predicting prognosis and complications.

Currently, there are several ongoing studies, funded by the Swiss Natio nal Science Foundation (SNSF): The international randomized controlled multicentre SWITCH trial (www. switch-trial.ch) assesses whether decompressive surgery and best medical treatment in patients with spontaneous intracerebral haemorrhage will improve outcome as compared to best medical treatment alone. Furthermore, a large study, sponsored by the Special Program University Medicine (SPUM) assesses the etiology, diagnosis and treatment of cervicocerebral artery dissections (EDIT CAD2). The Clinical Translational Sleep and Stroke Study Group studies the effects of sleep apnoea and other sleep disorders on stroke in humans, and the effects of sleep modulation on neuroplasticity processes and functional recovery in rodents. Furthermore, a randomised study analyses the effect early treatment of sleep apnoea with continues positive airway pressure (CPAP) in acute ischemic stroke patients and the effects of sleep apnoea and other sleep disorders on long term outcome of stroke.

The Neurovascular Research Group collaborates with the Support Center for Advanced Neuroimaging (SCAN) of the Institute of Diagnostic and Interventional Neuroradiology, and two new research units, the Center for Experimental Neurology (ZEN) and the Neuro Clinical Trial Unit (NCTU) which works in close cooperation with the Clinical Trials Unit (CTU) Bern. These groups will provide an optimal infrastructure for high quality translational and clinical research.

Groups

  • Neurovascular ResearchGroup

Focus

  • Development of new management approaches in acute stroke treatment
  • Management of patients with intracerebral haemorrhage
  • Pathogenesis and treatment of cervicocerebral artery dissection
  • Brain heart interaction
  • Role of sleep disorders (e.g sleep apnoea) on risk and outcome of stroke
  • Pathogenesis and treatment of stroke in neuroinfectious diseases

Delegates

Prof. Dr. med. Marcel Arnold Prof. Dr. med. Urs Fischer